Synthesis and preliminary evaluation of (S)-2-(4'-carboxycubyl)glycine, a new selective mGluR1 antagonist

R Pellicciari; G Costantino; E Giovagnoni; L Mattoli; I Brabet; J P Pin

doi:10.1016/s0960-894x(98)00265-0

Synthesis and preliminary evaluation of (S)-2-(4'-carboxycubyl)glycine, a new selective mGluR1 antagonist

Bioorg Med Chem Lett. 1998 Jun 16;8(12):1569-74. doi: 10.1016/s0960-894x(98)00265-0.

Authors

R Pellicciari¹, G Costantino, E Giovagnoni, L Mattoli, I Brabet, J P Pin

Affiliation

¹ Istituto di Chimica e Tecnologia del Farmaco, Università degli Studi, Perugia, Italy. rp@unipg.it

PMID: 9873392
DOI: 10.1016/s0960-894x(98)00265-0

Abstract

The synthesis and the pharmacological evaluation at metabotropic glutamate receptors of S-2-(4'-carboxy-cubyl)glycine (ACUDA, 9) are described. S-2-(4'-Carboxy-cubyl)glycine is a structurally novel group I selective antagonist for mGluR1 subtype.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bridged-Ring Compounds / chemical synthesis*
Bridged-Ring Compounds / chemistry
Bridged-Ring Compounds / pharmacology*
Cell Line
Excitatory Amino Acid Antagonists / chemical synthesis*
Excitatory Amino Acid Antagonists / chemistry
Excitatory Amino Acid Antagonists / pharmacology*
Glycine / analogs & derivatives*
Glycine / chemical synthesis
Glycine / chemistry
Glycine / pharmacology
Humans
Inositol Phosphates / biosynthesis
Inositol Phosphates / metabolism
Molecular Structure
Receptors, Metabotropic Glutamate / antagonists & inhibitors*
Transfection

Substances

2-(4'-carboxycubyl)glycine
Bridged-Ring Compounds
Excitatory Amino Acid Antagonists
Inositol Phosphates
Receptors, Metabotropic Glutamate
Glycine